Polymorphisms of the MTHFR gene are strongly associated with hypertension, and Met synthase 2756A > G and 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 66A > G polymorphisms related to folate metabolism may serve as genetic markers for hypertension risk (90, 91). The gene discussed is MTRR; the disease is hypertensive disorder.