These interactions between CAFs and cancer cells (Additional file 6 Additional files: 7, 8 and 9: Fig. S6A-D) were filtered, and a high-resolution map with the most relevant interactions of the PI3K-AKT pathway revealed the involvement of collagens, fibronectin, vitronectin, laminin, and osteopontin from CAFs with integrins in cancer cells (Fig. 5D). This evidence concerns the gene SPP1 and cancer.