From the total of 34 ligand and receptor genes identified in these interactions, seven (COL1A1, ITGB5, COL1A2, FGFR2, FN1, IGF1, and IGF2) were consistently up-regulated and predicted worse overall survival in two additional cohorts (TCGA and GSE9891) of ovarian cancer patients. Here, ITGB5 is linked to ovarian cancer.