It has also been reported that a relapsing disease course is more likely in patients with higher MOG-IgG titres at onset and persisting MOG-IgG over time, whereas transient low titres of MOG-IgG are typically associated with a monophasic disease course, not only in ADEM patients but also in other phenotypes [25]. The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.