MAPT and Alzheimer disease: In fact, earlier studies showed that P-tau prevents proper microtubule formation in patients suffering from Alzheimer’s disease by trapping the normal form of the tau protein (N-tau) and microtubule-associated proteins MAP1 and MAP2; interestingly, dissociation of hyperphosphorylated N-tau fibers by ultrasound restored their ability to bind N-tau (Alonso et al. 1996, 1997, 2006).