MAPT and early-onset autosomal dominant Alzheimer disease: In Alzheimer disease, it was indicated that pathological changes are related mainly to the hyperphosphorylation of the tau protein at Ser199 and Ser262, as well as Thr212 and Thr231 (Alonso et al. 1996, 2018), though it must be stressed that pathological changes found in this disease are not restricted to these phosphorylation sites.