Whereas PI3Kβ/δ inhibition resulted in an initial reduction of the activity of the AKT/mTOR/S6 axis in the majority of the DLBCLs, we observed a reactivation of the signaling pathway after 24 h in the AZD8186-resistant DLBCL models. The gene discussed is MTOR; the disease is diffuse large B-cell lymphoma.