Unfortunately, the Philadelphia chromosome (Ph)-a reciprocal translocation t(9;22)(q34;q11) leading to BCR-ABL fusion gene encoding BCR-ABL tyrosine kinase oncoprotein, is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) as well as ALL, that increases with age i.e., 2–5% in childhood, 6% in adolescents and young adults, and more than 25% in adults [4]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.