CD40 ligand, tumor necrosis factor (TNF), interleukin (IL) 6, IL2, IL23, C-X-C motif chemokine ligand 8 (CXCL8), and vascular endothelial growth factor were uniquely detected in OS vitreous humor but not in the unaffected OD eye. Here, CD40LG is linked to osteochondritis dissecans.