Indeed, 9-month-old Tg-AD rats have plaques in the entorhinal cortex, hippocampus and cortical arterioles54 as well as the DG and CA1 regions55 along with a doubling of tau phosphorylation at Ser202/Thr205 and a 1.5-fold increase in tau phosphorylation at Thr23154,56. This evidence concerns the gene MAPT and Alzheimer disease.