We performed IHC analyses of the hippocampus for GluA2 and PSD95 (Fig. 5A,B, whole hippocampus, C and D respective high magnifications panels, shown for Tg-AD rats; PSD95, red; GluA2, green; PSD95/GluA2 co-localization, yellow, indicated by white arrow heads). This evidence concerns the gene DLG4 and Alzheimer disease.