CD274 and neoplasm: The contradictory results of various studies can be explained by (1) overall paucity of CRCs expressing PD-L1 even in larger datasets, i.e., usually occurring in < 10% of probands, making it hard to reach statistical significance; (2) different methods of PD-L1 expression assessment either in terms of methodology (tumor proportion score—TPS, combined positive score—CPS, immune cell score—IC), or in terms of different antibodies (e.g., clones 22C3, and SP263), or in terms of percentage threshold value to regard a tumor as positive.