Our PD-L1 expression analysis in CRC is in line with the ambiguous results of the cited studies: we found a slight (borderline insignificant with p-value = 0.15) negative impact on OS and no impact on CSS, but there was significantly shorter OS in cases that strongly (> 49%) expressed PD-L1 on tumor cell membranes. This evidence concerns the gene CD274 and colorectal carcinoma.