To identify particularly aggressive CRC phenotypes, we analyzed a cohort similar to our previous study57 with nearly 10 years of follow-up focusing on the association between SATB2, CK7, and PD-L1 expression and correlations with traditional prognostic parameters such as stage, grade, anatomical site, and mismatch-repair (MMR) status along with prognostic implications. Here, CD274 is linked to colorectal carcinoma.