TP53 and hepatocellular carcinoma: ROS production and apoptotic cell detachment are also inhibited by CASP7 and CASP9.These caspases support the apoptotic pathways of CASP3. The TP53-BAX-caspase3 signaling pathway induced apoptosis of HCC cells by up-regulating TP53 and activating BAX and CASP3 protein expression24.