The expression of hub genes (AKT1, ESR1, and JUN) was down regulated and correlated against tumor-infiltrating levels negatively into LIHC; in contrast, up regulated hub genes (TP53 and CASP3) expression was correlated against all TIICs subsets positively into HCC (Fig. 7 A,E). Here, CASP3 is linked to hepatocellular carcinoma.