AKT1 and hepatocellular carcinoma: HPA immune histochemistry data revealed that TP53 and CASP3 protein expressions were positively up-regulated in HCC tissues compared to normal (Fig. 5A,D), whereas hubgenes AKT1, ESR1, and JUN protein expressions were negatively down-regulated in HCC tissues compared to normal (Fig. 5B,C,E).