IGFBP4, a protein significantly increased in abundance in EOPE (log2FC = 4.25, FDR = 0.0003) and LOPE (log2FC = 4.91, FDR = 0.004), compared to controls, is known to have anti-angiogenic properties9–12, adding further evidence to the central role of impaired angiogenesis in preeclampsia. The gene discussed is IGFBP4; the disease is preeclampsia.