We investigated associations between nonsynonymous mutations in 5 of the most commonly mutated genes in NSCLC (TP53, KRAS, EGFR, BRAF, PIK3CA) and copy number changes in 5 of the most commonly amplified genes (EGFR, PIK3CA, MET, KRAS, FGFR1) and the likelihood of developing metastases. The gene discussed is TP53; the disease is non-small cell lung carcinoma.