A comparative analysis in pancreas of Myc target genes induced by bi-allelic Rosa26 (MycERT2 levels analogous to those of wt endogenous Myc and competent to drive the transition of indolent KRasG12D-driven PanIN to pancreatic adenocarcinoma) versus mono-allelic Rosa26 (MycERT2 levels equivalent to hypomorphed endogenous Myc and insufficient to drive transition to adenocarcinoma) revealed varying impacts of Myc hypomorphism on Myc target gene expression. This evidence concerns the gene MYC and adenocarcinoma.