To narrow down the location of the bottleneck we then used a well-documented pancreatic adenocarcinoma mouse model in which KRasG12D activation is induced by Cre expression driven from the pdx promoter in pancreatic progenitor cells in early embryogenesis (E8)46, long before Myc hypomorphism is imposed in adult mice. The gene discussed is PODXL; the disease is pancreatic adenocarcinoma.