Mutations of EZH2 residue K683 (the equivalent of EZH1 residue K684) and SUZ12 residues H567, S568, D582, and S583 were all found in cancer cells, including established cancer cell lines and patient samples (Supplementary Fig. 8)57 (cancer.sanger.ac.uk/cosmic), suggesting the molecular interactions mediated by these residues may help maintain normal PRC2 function (Fig. 3c, d). The gene discussed is SUZ12; the disease is cancer.