Furthermore, downregulation of METTL14 alleviated cardiac fibrosis during I/R remodeling, as evidenced by Masson trichrome staining (Fig. 6i) and prevented increased expression of heart failure markers Anp, Bnp, β-Mhc, and α-Sma on mRNA levels (Fig. 6j). This evidence concerns the gene ACTA1 and heart failure.