Interestingly, like other previously reported factors and signaling pathways that have been known to be involved in exercise-induced cardiac hypertrophy, the PHLPP1 expression level was upregulated by METTL14 overexpression in response to swim training, though METTL14 overexpression did not regulate this in the control group (Supplementary Fig. 15d). This evidence concerns the gene PHLPP1 and cardiac hypertrophy.