MAP2K1 and central nervous system cancer: To investigate the role of Tpl2 and its association with HOXA11-AS in glioma, we demonstrated that the protein and phosphorylation levels of Tpl2, and activation of MEK1/2-ERK1/2, were induced by the ectopic expression of HOXA11-AS in U87 and LN229 cells (Fig. 4F–G).