Integrative GEPIA analysis of gliomas from TCGA (The Cancer Genome Atlas) and the human Genotype-Tissue Expression (GTEx) database [28], we found that PRMT3 was the most significantly enriched factor among all the PRMTs (based on fold change and p value) in both GBM and LGG (Fig. 1A, B). This evidence concerns the gene PRMT3 and central nervous system cancer.