PRMT6 has been shown methylate RCC1 (regulator of chromatin condensation 1) at arginine 214 to facilitate RCC1 association with chromatin and RAN-GTPase activation, which enhances mitotic activity in GSCs and facilitates nucleocytoplasmic transport during interphase, thereby promoting GBM cell proliferation and therapy resistance [13]. Here, RCC1 is linked to glioblastoma.