In contrast, PRMT3 knockdown significantly decreased HIF1A expression under hypoxia conditions (1% O2 or CoCl2-induced hypoxia [39]), which elevates HIF1A expression [40] in U251 and GSC262 GBM cells assayed by western blotting (Fig. 7D, E). The gene discussed is HIF1A; the disease is glioblastoma.