Mutation of the protease cleavage site of RHBDL2 or knockdown of OTUD7B in RHBDL2-overexpressing PC cells rescued their enhanced proliferation (Fig. 7A–C), migration, and invasion (Fig. 7D, E) capacity mediated by the RHBDL2. The gene discussed is RHBDL2; the disease is pachyonychia congenita.