Bioluminescent tumor burden was also significantly decreased by a single infusion of PRDM1/NR4A3 KO PSMA CAR T-cells compared to AAVS1 KO (P < 0.05) CAR T-cells in mice bearing intraosseous tumors generated by PC3-PSMA cell engraftment (Fig. 7C). This evidence concerns the gene NR4A3 and neoplasm.