NR4A3 and neoplasm: Next, we assessed effector functions in the context of PRDM1/NR4A3 KO and found that PRDM1/NR4A3 KO CAR T-cells maintained an elevated abundance of effector cytokine production after multiple tumor challenges, whereas PRDM1 and NR4A3 single KO CAR T-cells showed similar IL-2 and TNF-α secretion as control CAR T-cells (Fig. 5D and E).