FSHR encode follicle-stimulating hormone (FSH), and anydysfunctions in this receptor may disturb the function of follicles and ovaries(Ajmal et al., 2019).Mutations which inactivate FSHR will lead to hypergonadotropic hypogonadism, whichcan cause the follicles to stagnate in the preantral state (McAllister et al., 2015). The gene discussed is FSHR; the disease is Hypergonadotropic hypogonadism.