SYNCRIP and dentin dysplasia: For example, SYNCRIP (OMIM: 616686), a gene already strongly implicated in NDDs (44, 45), shows one dnMIS and two dnLGD variants in DD patients as well as two dnLGD variants in ASD patients in this dataset; it reaches FDR significance supported by all three models and FWER significance by the CH model when combined but no significance when ASD and DD are analyzed separately.