After literature and database searches (e.g., DDG2P, SFARI Gene, OMIM, PubMed), filtering for GTEx brain tissue expression, and pLI intolerance as mentioned above, we highlight five genes (PABPC1, MARK2, SF3B2, CDKN2AIP, and RTF1) as compelling candidates with a potential association with NDDs and are replicated by a case-control design with autism probands. The gene discussed is SF3B2; the disease is autism.