For example, KMT2E encodes a member of the lysine N-methyltransferase-2 family of chromatin modifiers, is associated with O’Donnell-Luria-Rodan syndrome, and shows a male bias in our data (16 DNVs in males versus three in females); finally, KDM6B shows 12 DNVs in males compared to two events in females and encodes a histone H3K27 demethylase that specifically demethylates di- or trimethylated lysine-27 (K27) of histone H3 (Table 3 and Fig. 5). The gene discussed is KDM6B; the disease is O'Donnell-Luria-Rodan syndrome.