As expected, genes reaching significance in the broader NDD supergroup show DNVs in both ASD and DD patients, but 10 genes reach genome-wide significance only when cohorts are combined as a broader NDD group (MYT1L, PHF21A, FBN1, PBX1, GNB2, PABPC1, CLCN4, NALCN, PSMC5, and CERT1), highlighting the value of this integrated analysis. Here, CLCN4 is linked to Neurodevelopmental delay.