ACHE and early-onset autosomal dominant Alzheimer disease: Donepezil (1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine) shown in Fig 1 is a known potent human acetylcholinesterase (AChE) inhibitor used clinically in the management of symptoms associated with mild to severe Alzheimer’s disease [1, 2].