Sympathomimetics lower [K+] by stimulation of the sodium–potassium ATPase pumps, causing an intracellular shift in potassium.6 Of note, sympathomimetic therapy in conjunction with insulin and dextrose is first-line therapy for all-cause hyperkalemia in people.8 Frequency of sympathomimetic use to treat hyperkalemia in cats in the general veterinary emergency community is unknown. The gene discussed is INS; the disease is Hyperkalemia.