Finally, by comparing the TCRs of cluster 04, 05 T cells and tetramer-sorted T cells specific to tumor neoantigen Adpgk, we observed a significant enrichment of convergent TCRs for neoantigen specificity in cluster 04 (OR = 4.41, p<0.001), while no enrichment in cluster 05 (Figure 3—figure supplement 1B). The gene discussed is ADPGK; the disease is neoplasm.