PRF1 and neoplasm: CD8-05-FGFBP2 cluster exhibited a CD8+ effector phenotype, upregulating genes involved in cytotoxicity and anti-tumor activity: FGFBP2, GNLY, FCGR3A (Zheng et al., 2017), GZMH, PRF1, TGFBR3, and GZMB (Figure 3E).