In myeloid cells, the top 50 pan-cancer central genes included seven genes involved in myeloid cell differentiation (CD4, FCER1G, IRF8, TYROBP, TLR2, TREM2 and ITGAM), but only two of them (FCER1G and TYROBP) were found among the top 50 DEGs. Here, IRF8 is linked to cancer.