Thus, dynamic changes of irisin in peripheral circulation seem to be powerful predictor of cardiac remodeling and HF irrespectively from its phenotypes, whereas it remained uncertain whether irisin is comparable to NT-proBNP in its predictive ability in T2DM patients and if add-on of irisin to NT-proBNP is able to improve discriminative potency of the combination. This evidence concerns the gene FNDC5 and hydrops fetalis.