Univariate logistic regression model yielded that the predictors for HF in patients enrolled in the study were the following factors: irisin < 10.4 ng/mL, LV hypertrophy, BMI, NT-proBNP > 750 pmol/mL, age, LAVI > 34 mL/m2 and E/e’ > 11 (Table 3). The gene discussed is FNDC5; the disease is hydrops fetalis.