D2HGDH and central nervous system cancer: Notably, they have identified 2 novel genetic loci and a GWAS-reported region associated with the risk of specific glioma molecular subtypes: rs5839764 (2q37.3; D2HGDH) for IDH mutation; rs1106639 (2q37.3; D2HGDH) for IDH mutation and 1p/19q non-codeletion; rs111976262 (7p22.3; FAM20C) for triple-positive (IDH mutation, TERT mutation and 1p19q co-deletion); and rs4809313 (20q13.33; GMEB2) for IDH wild-type.