To date, a total of 12 SNPs in 10 loci have been associated with the risk of pan-glioma, with odds ratios (ORs) ranging from 1.18 for rs2252586 (7p11.2; EGFR)61 and rs498872 (11q23.3; PHLDB1)62 to 3.55 for rs688755 (19p13.12; CYP4F12)63. Here, PHLDB1 is linked to central nervous system cancer.