The average time from diagnosis to transformation was 58.8 months for all patients with IDH-mutant LGGs (range, 5.9–208.1); 58.4 and 78.1 months for 1p/19q-non-codeleted and codeleted LGGs, respectively (Figure 1A and 1B); and 63.5 and 51.9 months for grade 2 and grade 3 gliomas, respectively (Figure 1C and 1D). This evidence concerns the gene IDH2 and central nervous system cancer.