In a preclinical model of Alzheimer’s dementia, tau induces dissociation of nNOS from postsynaptic density protein 95 (PSD95) in the post-synaptic neuron, impairing NVC.35 This points to a role for NVC integrity as a disease biomarker, and also potentially identifies nNOS as a therapeutic target capable of improving function by enhancing NVC. Here, NOS1 is linked to Alzheimer disease.