Tissue specificity may explain why SHP‐2 and other RAMP/PAE variants have not been found associated with any testicular cancers (COSMIC v94 [Forbes et al., 2017]) and are even absent in a rare testis cancer typically found only in elderly men (spermatocytic seminomas (Goriely et al., 2009) where it most likely would have been expected). Here, PTPN11 is linked to spermatocytic seminoma.