In addition, SHP‐2 phosphatase activity of the three tested PTPN11 S‐O cancer variants, shown in Figure 5e, are significantly higher than the recurrent NS1 variants (p value <3 × 10−5, explained in Methods S7) confirming earlier work (Bocchinfuso et al., 2007; Keilhack et al., 2005; Martinelli et al., 2008, 2012; Niihori et al., 2005; Pannone et al., 2017; Tartaglia et al., 2006). Here, PTPN11 is linked to cancer.