PTPN11 and hematopoietic and lymphoid system neoplasm: We call 20 of the 35 E3 sporadic blood cancer sites S‐O as they were previously classified as unassociated with NS1 and were recognized as having SHP‐2 tyrosine phosphatase hyper‐activation levels that would likely prevent germline transmission due to early developmental failure (Lee et al., 2009; Niihori et al., 2005; Tartaglia et al., 2003, 2006).