MUC5AC and malignant colon neoplasm: For example, although some studies reported that the significant reduction of goblet cell number is a striking feature of colon cancer [7], goblet cells are also considered as key sources of oncogenetic mucin secretion responsible for constitutive activation of growth and survival pathways and downregulation of stress‐induced death pathways [8] and are especially enriched in BRAF mutant colon cancer, a highly aggressive disease subtype [9].