MUC2 and neoplasm: For example, although overexpression of MUC2, the marker of goblet cells, was shown to be associated with increased colon cancer risk and tumor development [33], some studies in the literature have also indicated that MUC2 secreted by goblet cells can exert an anti‐cancer effect by protecting the intestinal mucosa [33] and the loss of MUC2 expression was a predictor of adverse outcomes [34].