ITM2B and Mental deterioration: γ oscillations correlate with learning, memory, cognition and other higher processes in the brain40,41 and progressive cognitive decline observed in AD goes hand-in-hand with a progressive decrease of γ oscillations.42–44 The recombinant BRICHOS domains from human proSP-C and Bri2 can efficiently prevent Aβ42-induced decline in hippocampal γ oscillations, observed for Aβ42 concentrations from 50 nmol L−1 to 1 μmol L−1.