The four genes have been found to influence tumor progression in HNSCC via necroptosis regulation; Poly (ADP-ribose) polymerase-1 (PARP1), as a chromatin-associated enzyme in DNA repair; and a downstream effector of RIPK1/RIPK3 pathway in necroptosis [53]. This evidence concerns the gene PARP1 and head and neck squamous cell carcinoma.