As an important component of APA, CPSF is usually upregulated in cancers, such as CPSF1 in HCC and ovarian cancer [8,22], CPSF3 in HCC [17], CPSF4 in colorectal and lung cancers [9,10], and CPSF7 in HCC [12]. This evidence concerns the gene CPSF3 and cancer.