For example, CPSF4 knockdown inhibits the PI3K/AKT pathway in LUAD [10]; CPSF3 knockdown inhibits the PI3K/AKT pathway in HCC [17]; CPSF7 knockdown inhibits the PTEN/AKT pathway in HCC [12]. The gene discussed is CPSF4; the disease is hepatocellular carcinoma.