Previous studies on pure DCIS or DCIS adjacent to IDC diagnosed by any breast imaging technique (primarily mammography) reported that these diagnoses were more prevalent in BRCA2 PSV carriers than in BRCA1 PSV carriers—Arun et al. analyzed 73 BRCA1/2 PSV carriers—70% of BRCA2 carriers had preinvasive lesion adjacent to the IDC, in comparison to 52% of BRCA1 [18]. Here, BRCA1 is linked to ductal breast carcinoma in situ.