In conclusion, noncalcified MRI-only diagnosed DCIS is an important entity that is diagnosed by adhering to an annual MRI screening of female BRCA PSV carriers, more frequently in BRCA1 than in BRCA2, and in these BRCA1 PSV carriers, the tumor is more likely to be estrogen receptor negative and displays high-grade phenotype. The gene discussed is ESR1; the disease is neoplasm.