Absence seizures are the most prevalent seizure type in SYNGAP1 haploinsufficiency patients, with 53/57 cases having absence seizures in a recent clinical report.3Syngap+/Δ−GAP are to our knowledge, the only pre-clinical model of SYNGAP1 with spontaneous absence seizures.17 Replication of such an important phenotype suggests that this model has a high face validity and therefore biomarkers identified here may have particular translational relevance. This evidence concerns the gene SYNGAP1 and juvenile absence epilepsy.