In this study, we tapped into the comprehensive clinical datasets of the DFP pilot cohort9 (Supplementary Table 1), we generated thirteen sporadic Alzheimer’s disease iPSC lines and one familial Alzheimer’s disease iPSC line (Patient #5) carrying an autosomal dominant APP mutation, for use in our experiments (Supplementary Table 2 and Supplementary Fig. 5). The gene discussed is APP; the disease is familial Alzheimer disease.