Previously, a case of extreme resilience or resistance to amyloid has been reported in a person with an autosomal dominant mutation causative of Alzheimer’s disease who remained free from dementia late in life despite evidence of very extensive amyloid deposition.32 Sequencing suggested her apparently complete resilience was due to possession of two copies of a rare variant in APOE ε3 (‘Christchurch’). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.