JPX and cancer: Functional validation was performed for putative peptides from three such LncRNAs: (i) the nuclear lncRNA JPX, which plays roles in regulating X-chromosome inactivation in mammalian cells (103,104) and has also been shown to regulate several cancers (98,99), (ii) the generally cytoplasmic lncRNA CRNDE, whose role in colorectal cancer is already well established (100,101), and iii) the lncRNA LINC00467, whose roles in multiple cancers are now starting to be well established (105–107).