To develop a complementary model that contains a concomitantly passaged castration-resistant control from human PCa cells (which is not available for the LNCaP and MR49F cell lines), we used a similar approach with the wild-type AR VCaP cell line (59) (i.e. AR is mutated in LNCaP cells (61)) (Table 1). This evidence concerns the gene AR and posterior cortical atrophy.