Reduce arthritis signs and release of NO and IL‐17 inflammatory cytokine. Carvacrol‐mitigated LPS‐induced cell proliferation, migration, and inflammation in RA‐FLSs. The TLR4/MyD88/NF‐κB, p38, and ERK1/2 pathways might be involved in the protective effect of carvacrol. Here, TLR4 is linked to arthritic joint disease.