This study showed for the first time that extracellular vesiclessecreted by the metastatic melanoma cell lines mel H, mel Kor, and mel Pcontain, both at the mRNA and protein levels, the α7-type nicotinicacetylcholine receptor (α7-nAChR), which is involved in the regulation ofthe oncogenic signaling pathways in epithelial cells. Here, CHRNA7 is linked to melanoma.