The targets of this highlypathogenetically promising family of microRNAs include mRNAs of the PARK-7(DJ-1) gene, whose mutations can lead to PD, GPR37 mRNA, with its substratebeing the parkin protein associated with the development of early PD, andvarious regulators of apoptosis processes (Puma, Bim, Bak, Bcl2, IGF1, AKT1).The targets of individual microRNAs from the miR-29 family can significantlyoverlap, but their role in the pathogenesis of various PD forms is beyonddoubt. The gene discussed is PRKN; the disease is Parkinson disease.