Earlier, we have demonstrated that most SARS-CoV-2 anti-RBD antibodiesin patients who had had COVID-19 were conformationally dependent [16, 26].CoviVac apparently has an appreciably low immunogenicity, which is probablycaused by partial disruption of the structure of the S-protein epitopes duringvirus inactivation or storage. The gene discussed is PROS1; the disease is COVID-19.