Peroxisome proliferator-activatedreceptor-γ 1α coactivator (PGC-1α) is a master regulator ofmitochondrial biogenesis, energy metabolism, and respiration throughinteractions with various transcription factors, including nuclear respiratoryfactors 1 (NRF-1) and 2 (NRF-2) [84].Qin et al. were the first to show a decrease in PGC-1α expression in ADpatients and a transgenic mouse model of AD [85]. This evidence concerns the gene PPARGC1A and Alzheimer disease.