The IL-2 diphtheria toxin conjugate Denileukin Diftitox (IL2DT), composed of the amino acid sequences for diphtheria toxin followed by truncated IL-2, is used to selectively deplete CD25-expressing Tregs and allow PB-NK cell expansion and in vivo function by the Masonic Cancer Center (Additional file 3: Table S3, row 1) [27]. The gene discussed is IL2; the disease is cancer.