FCGR3A and neoplasm: CD16a is an endogenous surface receptor expressed by cytotoxic NK cells which recognizes the constant fragment crystallizable (Fc) region of immunoglobulin (Ig)G antibodies bound to TAAs on target cancer cells, thereby initiating a potent cascade of signals resulting in anti-tumor responses mediated through cytokine secretion and recruitment of adaptive immune cells, known as antibody-dependent cellular cytotoxicity (ADCC) [183].