VEGFA and cancer: Meanwhile, according the main MR estimates from IVW analyses of this study, we quantified that one SD increase in VEGF level may increase 6.4% probability for VTE development and 6.7% probability for DVT_PE development, which were consistent with above observational studies to some extent and further strengthened the potential evidence that VEGF is a suggestive causal risk factor for VTE (independent of cancer or other relative diseases), suggesting that cancer or relative diseases are not likely mediator or confounder of VEGF-VTE relationship.