A recent study of the FDA approved anthelmintic drug pyrvinium pamoate in AML showed that it induced apoptotic cell death in FLT3-ITD harboring AML cell lines at low nanomolar concentrations via activation of the ISR, as shown by phosphorylation of eIF2α and upregulated expression of ATF4 [80]. Here, ATF4 is linked to acute myeloid leukemia.