A role for ATF4 has also been shown in the pathogenesis of Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) AML as it was shown that the mutant FLT3-ITD protein stimulates ATF4-dependent autophagy to support the proliferation of AML cells [59]. This evidence concerns the gene FLT3 and acute myeloid leukemia.