Immunofluorescence assay further confirmed that the level of PKM2 (p-Y105) in CRC-infiltrating CD11b+ myeloid cells was significantly increased in colon tumor tissues of C. tropicalis-colonized mice with CAC, which could be suppressed by TEPP-46 treatment (Fig. 7G). The gene discussed is ITGAM; the disease is colorectal carcinoma.