PHB1 and Alzheimer disease: The authors found that the decrease in the levels of PHB1 and PHB2 will cause the level of PHB1-PHB2 complex to decrease, and the PHB1-PHB2 complex modulates mitochondrial dynamics by reducing the generation of free radicals, and the complex assembly of mitochondrial respiration participates in the beneficial effects of neurons, and in the middle and late stages of AD, the expression of PHB1 subtypes phosphorylated at Thr258 and Y259 declines.