However, others have found that the odds ratio of APOE2/4 individuals is more similar to that of APOE4 carriers than APOE2 carriers [21], suggesting that the increased risk associated with APOE4 is more dominant than the protection offered by APOE2. The multitude of pathological pathways by which apoE impacts AD risk and disease progression makes it an ideal therapeutic target for AD [24]. This evidence concerns the gene APOE and Alzheimer disease.