SCUBE1 can bind to the BMP domain to inhibit tumour growth, and the serum content of SCUBE1 in gastric cancer patients is significantly higher than that in healthy people.[16, 17] Emerging studies have reported a pivotal role of the SCUBE family as an important upstream regulator in regulating the secretion of Sonic Hedgehog (Shh) protein. The gene discussed is SCUBE1; the disease is neoplasm.